The Protein Ontology (PRO) provides a formal, logically-based classification of specific protein classes including structured representations of protein isoforms, variants and modified forms. Initially focused on proteins found in human, mouse and Escherichia coli, PRO now includes representations of protein complexes. The PRO Consortium works in concert with the developers of other biomedical ontologies and protein knowledge bases to provide the ability to formally organize and integrate representations of precise protein forms so as to enhance accessibility to results of protein (...) research. PRO (http://pir.georgetown.edu/pro) is part of the Open Biomedical Ontologies (OBO) Foundry. (shrink)

The nested continua model is a visual methodological device, consisting in the graphic representation of a series of concentric circles representing successive contexts, within which a particular problem can be examined, ranging from the most specific to the least specific. It is ‘not fundamentally about Peirce’ (p. 3); however, Slater draws on Peirce’s ability to accommodate ‘distinctions of enormous gravity’ (p. 4) required in theology and acknowledges that his own model is analogous to Peirce’s Existential Graphs.

Online data collection methods are expanding the ease and access of developmental research for researchers and participants alike. While its popularity among developmental scientists has soared during the COVID-19 pandemic, its potential goes beyond just a means for safe, socially distanced data collection. In particular, advances in video conferencing software has enabled researchers to engage in face-to-face interactions with participants from nearly any location at any time. Due to the novelty of these methods, however, many researchers still remain uncertain about (...) the differences in available approaches as well as the validity of online methods more broadly. In this article, we aim to address both issues with a focus on moderated data collected using video-conferencing software. First, we review existing approaches for designing and executing moderated online studies with young children. We also present concrete examples of studies that implemented choice and verbal measures and looking time across both in-person and online moderated data collection methods. Direct comparison of the two methods within each study as well as a meta-analysis of all studies suggest that the results from the two methods are comparable, providing empirical support for the validity of moderated online data collection. Finally, we discuss current limitations of online data collection and possible solutions, as well as its potential to increase the accessibility, diversity, and replicability of developmental science. (shrink)

A substantial body of evidence suggests that autobiographical recollection and simulation of future happenings activate a shared neural network. Many of the neural regions implicated in this network are affected in patients with bipolar disorder , showing altered metabolic functioning and/or structural volume abnormalities. Studies of autobiographical recall in BD reveal overgeneralization, where autobiographical memory comprises primarily factual or repeated information as opposed to details specific in time and in place and definitive of re-experiencing. To date, no study has examined (...) whether these deficits extend to future event simulation. We examined the ability of patients with BD and controls to imagine positive, negative and neutral future events using a modified version of the Autobiographical Interview that allowed for separation of episodic and non-episodic details. Patients were selectively impaired in imagining future positive, negative, and neutral episodic details; simulation of non-episodic details was equivalent across groups. (shrink)

Objective Although patients exercise greater autonomy than in the past, and shared decision making is promoted as the preferred model for doctor-patient engagement, tensions still exist in clinical practice about the primary locus of decision-making authority for complex, scarce, and resource-intensive medical therapies: patients and their surrogates, or physicians. We assessed physicians’ attitudes toward decisional authority for adult venoarterial extracorporeal membrane oxygenation (VA-ECMO), hypothesizing they would favor a medical locus. Design, Setting, Participants A survey of resident/fellow physicians and internal medicine (...) attendings at an academic medical center, May to August 2013. Measurements We used a 24-item, internet-based survey assessing physician-respondents’ demographic characteristics, knowledge, and attitudes regarding decisional authority for adult VA-ECMO. Qualitative narratives were also collected. Main Results A total of 179 physicians completed the survey (15 percent response rate); 48 percent attendings and 52 percent residents/ fellows. Only 32 percent of the respondents indicated that a surrogate’s consent should be required to discontinue VA-ECMO; 56 percent felt that physicians should have the right to discontinue VA-ECMO over a surrogate’s objection. Those who self-reported as “knowledgeable” about VA-ECMO, compared to those who did not, more frequently replied that there should not be presumed consent for VA-ECMO (47.6 percent versus 33.3 percent, p = 0.007), that physicians should have the right to discontinue VAECMO over a surrogate’s objection (76.2 percent versus 50 percent, p = 0.02) and that, given its cost, the use of VA-ECMO should be restricted (81.0 percent versus 54.4 percent, p = 0.005). Conclusions Surveyed physicians, especially those who self-reported as knowledgeable about VA-ECMO and/or were specialists in pulmonary/ critical care, favored a medical locus of decisional authority for VA-ECMO. VA-ECMO is complex, and the data may (1) reflect physicians’ hesitance to cede authority to presumably less knowledgeable patients and surrogates, (2) stem from a stewardship of resources perspective, and/or (3) point to practical efforts to avoid futility and utility disputes. Whether these results indicate a more widespread reversion to paternalism or a more circumscribed usurping of decisional authority occasioned by VA-ECMO necessitates further study. (shrink)

Against the background of degeneration and the perceived threat to the nation’s health and stock, family politics came to constitute an important site for eugenic discourses and interventions. Eugenic regulation of reproductive sexuality and marriage was not only pursued through ‘negative’ eugenics but also through educational policies targeted at young adults and youth. Switzerland serves as a useful case to explore a general idea, namely the limitations for eugenicists of exploiting the concept of a rational subject in order to achieve (...) their ends. Practices of ‘positive eugenics’ crucially hinged on the utilitarian principle of rationality underpinning positive eugenics which this paper seeks to elaborate. Eugenicists devised tools to deal efficiently with social problems on a collective as well as an individual basis by deploying technologies of government which conceived individuals to be members of a population who were each held responsible for the generation of healthy future generations. As a form of ‘sustaining, multiplying and ordering life’ eugenics thus relied on the premise that its ideas would be adopted through an appeal to rationality and, where this was insufficient, through a series of coercive measures. Relying on conviction and education about the merits of eugenics, however, posed particular problems to positive eugenic thinking and practice. (shrink)

La traduction peut jouer un rôle fondamental dans la création des concepts philosophiques. C'est ce qui se passe depuis 1990 en Russie, après l'effondrement de l'idéologie soviétique. Mais le fait n'est pas radicalement nouveau. Dès l'époque de Pierre le Grand, Vassili Trediakovski travailla à créer en russe des concepts correspondant à ceux de la philosophie européenne. On rencontre un processus semblable à l'époque postnapoléonienne, ainsi qu'au début du XXe siècle. De nos jours, ce sont des auteurs comme Foucault, Derrida, Deleuze, (...) Lacan et Lyotard qui, chacun à sa manière, sont accueillis en Russie, où se créent ainsi des concepts philosophiques spécifiques. Translation may play a fundamental part in the creation of philosophical concepts. Such is what happens in Russsia since 1990 after the collapse of Soviet ideology. But the fact is not radically new. As early as Peter the Great times, Vassili Trediakovski worked at creating inRussian quite a few concepts corresponding to those of European philosophy. A similar process is also to he come across during the post-Napoleonic days and at the beginning of the 20 century. Presently, authors such as Foucault, Derrida, Deleuze, Lacan and Lyotard, every one in his own way, are welcomed in Russia where specific philosophical concepts are thus created. (shrink)

We present a theory of cooperative-competitive intelligence (CCI), its measures, research program, and applications that stem from it. Within the framework of this theory, satisficing sub-optimal behavior is any behavior that does not promote a decrease in the prospective control of the functional action diversity/unpredictability (D/U) potential of the agent or team. This potential is defined as the entropy measure in multiple, context-dependent dimensions. We define the satisficing interval of behaviors as CCI. In order to manifest itself at individual or (...) team level, this capacity harnesses properties such as degeneracy, pleiotropy (pluri-potentiality), synergies, and metastability. Intelligence is embodied because intelligent behavior is deeply dependent on body functionalities, defined as entropy measures. We base our theory on three principles: (a) relativity of functional entropy/ information in agent (team)-environment systems, (b) tendency toward the satisficing level of D/U potential, and (c) tendency toward the non-decreasing D/U potential. The conjunction of these three principles provides existence of sub-optimal behaviors associated with CCI. First, we deal with the problem of how to reduce multidimensional behavior to a concept that accounts for the vast set of scenarios in which CCI is manifested. Secondly, we define and discuss the three interacting principles that underpin CCI behavior as well as providing an outline for a future CCI research program supported by agent￾based modeling and empirical research. Finally, we provide some preliminary practical issues that stem from the theory. (shrink)

Idealization is commonly understood as distortion: representing things differently than how they actually are. In this paper, we outline an alternative artifactual approach that does not make misrepresentation central for the analysis of idealization. We examine the contrast between the Hodgkin-Huxley (1952a, b, c) and the Heimburg-Jackson (2005, 2006) models of the nerve impulse from the artifactual perspective, and argue that, since the two models draw upon different epistemic resources and research programs, it is often difficult to tell which features (...) of a system the central assumptions involved are supposed to distort. Many idealizations are holistic in nature. They cannot be locally undone without dismantling the model, as they occupy a central position in the entire research program. Nor is their holistic character mainly related to the use of mathematical and statistical modeling techniques as portrayed by Rice (2018, 2019). We suggest that holistic idealizations are implicit theoretical and representational assumptions that can only be understood in relation to the conceptual and representational tools exploited in modeling and experimental practices. Such holistic idealizations play a pivotal role not just in individual models, but also in defining research programs. -/- . (shrink)

La descripción del itinerario investigador de la biología de las células troncales permite una reflexión sobre la racionalidad de la creatividad científica. En 1998 aparecieron las células troncales procedentes de embriones humanos. Inmediatamente llegaron, motivadas por razones ideológicas, políticas y económicas, las especulaciones sobre sus posibilidades terapéuticas. Pero las dificultades para su uso médico resultaron insuperables. En 2007 aparecieron las células troncales humanas de pluripotencialidad inducida (iPS). Esta trayectoria investigadora revela aspectos claves del pensamiento creativo en ciencia: a) La importancia (...) de la motivación ética para encontrar un punto de partida no destructivo que marca la racionalidad del camino: los procesos fisiológicos ocurren en la unidad de un organismo vivo. b) La necesidad de un conocimiento profundo de la experiencia científica acumulada para escoger la vía más natural. c) La visión de futuro que agota las posibilidades que ofrecen las pruebas en animales, y que encuentra aplicaciones útiles a los conocimientos que se van obteniendo. d) La imprescindible responsabilidad sobre las consecuencias. (shrink)

We carried out a systematic review of psycholinguistic, empirical, quantitative studies on verbal irony use and individual differences (i.e. psychological, not demographic, traits that significantly differentiate individuals). Out of 5,967 publications screened, 29, comprising 35 studies in total, were included. Following a qualitative content analysis, six thematic clusters were identified, representing areas of research in individual differences in irony use: (a) psychological well-being, (b) personality traits, (c) humor-related traits, (d) cultural factors, (e) social skills, and (f) cognitive factors. The results (...) of the studies in each cluster are summarized and conclusions for further research are presented. In particular, the systematic review suggests that irony and sarcasm should be clearly delineated as separate, yet related phenomena due to differing patterns of correlations with specific individual differences. Additionally, significant methodological heterogeneity between the studies suggests the need for greater standardization of irony use measures. (shrink)

Este trabajo analiza, desde una perspectiva sociodemográfica, el comportamiento de la mortalidad adolescente en Argentina, más allá de las causas externas, en los trienios 2005-2007 y 2015-2017. Para ello, se calculan y analizan tasas de mortalidad por sexo, grupo de edad, causas seleccionadas y regiones geográficas, con base en datos de la Dirección de Estadística e Información de Salud de la Nación y del Instituto Nacional de Estadísticas y Censos. También se calculan el Coeficiente de Gini y los Años de (...) Esperanza de Vida Perdidos a nivel regional para profundizar el análisis de la dinámica espacial de la mortalidad. Los resultados muestran una reducción de la mortalidad adolescente para el conjunto de causas no externas. Sin embargo, se observan además: (a) mayores tasas de mortalidad masculina; (b) un aumento de la mortalidad en la población de 15 a 19 años de ambos sexos; (c) el predominio de los tumores como principal causa de muerte no externa; (d) un aumento de la mortalidad por enfermedades del sistema nervioso central, del aparato circulatorio, respiratorias y causas maternas, fundamentalmente entre los 15 y 19 años; y (e) la persistencia de diferencias interregionales, mayormente en detrimento del Noreste y del Noroeste. Estos resultados refuerzan la importancia de emprender medidas focalizadas en las particularidades de cada región y los factores que inciden en la ocurrencia de las muertes registradas. Todo ello en favor de procurar una atención más integral de la salud de la población adolescente, y lograr así sociedades más saludables y sostenibles a futuro. (shrink)

(CONTENIDO: LA FILOSOFÍA DE ALTHUSSER A 50 AÑOS DE LIRE LE CAPITAL Pedro Karczmarczyk, 3; DISCURSO Y DECRETO: SPINOZA ALTHUSSER Y PÊCHEUX Warren Montag 11; ALTHUSSER LECTOR DE GRAMSCI Vittorio Morfino 43 LAS ABSTRACCIONES, ENTRE LA IDEOLOGÍA Y LA CIENCIA João Quartim de Moraes 67 ELOGIO DEL TEORICISMO. PRÁCTICA TEÓRICA E INCONSCIENTE FILOSÓFICO EN LA PROBLEMÁTICA ALTHUSSERIANA, Natalia Romé 85 MARXISMO Y FEMINISMO: EL RECOMIENZO DE UNA PROBLEMÁTICA1 115 Luisina Bolla* / Pedro Karczmarczyk* 115 RRESEÑAS El materialismo de Althusser. (...) Más allá del telos y del Eschaton de Vittorio Morfino, por Valentín Huarte 153; El sujeto en cuestión, Pedro Karczmarczyk (ed.) por Constanza Storani; 159 La posición materialista. El pensamiento de L. Althusser entre la práctica teórica y la práctica política, de Natalia Romé, por Ingrid Sarchman y Carolina Collazo 164. (shrink)

In this article I try to refute the so-called "libertarian" theory of free will, and to examine how our conclusion ought to modify our common attitudes of praise and blame. In attacking the libertarian view, I shall try to show that it cannot be consistently stated. That is, my dscussion will be an "analytic-philosophic" one. I shall neglect what I think is in practice an equally powerful method of attack on the libertarian: a challenge to state his theory in such (...) a way that it will fit in the modern biology and psychology, which are becoming increasingly physicalistic. (shrink)

Prompted and ever diversified by the specifically human interrogative logos, scientific inquiries seek a common system of links in order to mutually confirm and rectify their results. Coming closer and closer to phenomenology, the sciences of life find the common ground of the reality in the ontopoiesis of life. Could it not be that the interrogative logos of science, participating in human creative inventiveness will bring together also the divergent scientific methods in a common network? A network which comprises natural (...) processes, societal sharing-in-life, and existential communication. Papers by: Gary Backhaus, Anjana Bhattacharjee, Simon Du Plock, Ignacy Fiut, Maria Golaszewska, Wendy C. Hamblet, Alexandr Kouzmin, Nikolay Kozhevnikov, Olga Louchakova, Jarlath Mc Kenna, Amy Louise Miller, Aria Omrani, Arthur Piper, Leszek Pyra, W. Kim Rogers, A.L. Samian, Camilo Serrano Bonitto, Natalia Smirnova, Eva Syristova, Anna-Teresa Tymieniecka, Roberto Verolini, Eldon C. Wait, Leo Zonneveld. (shrink)

In our papers on the rationality of magic, we distinghuished, for purposes of analysis, three levels of rationality. First and lowest (rationalitYl) the goal directed action of an agent with given aims and circumstances, where among his circumstances we included his knowledge and opinions. On this level the magician's treatment of illness by incantation is as rational as any traditional doctor's blood-letting or any modern one's use of anti-biotics. At the second level (rationalitY2) we add the element of rational thinking (...) or thinking which obeys some set of explicit rules, a level which is not found in magic in general, though it is sometimes given to specific details of magical thinking within the magical thought-system. It was the late Sir Edward E. Evans-Pritchard who observed that when considering magic in detail the magician may be as consistent or critical as anyone else; but when considering magic in general, or any system of thought in general, the magician could not be critical or even comprehend the criticism. Evans-Pritchard went even further: he was sceptical as to whether it could be done in a truly consistent manner: one cannot be critical of one's own system, he thought. On this level (rationalitY2) of discussion we have explained (earlier) why we prefer to wed Evans Pritchard's view of the magician's capacity for piece-meal rationality to Sir James Frazer's view that magic in general is pseudo-rational because it lacks standards of rational thinking. (shrink)

The flowering of creative and speculative philosophy that emerged in modern Europe--particularly in Germany--is a thrilling adventure story as well as an essential chapter in the history of philosophy. In this integrative narrative, Solomon provides an accessible introduction to the major authors and movements of modern European philosophy, including the Enlightenment and Romanticism, Rousseau, German Idealism, Kant, Fichte, Schelling and the Romantics, Hegel, Schopenhauer, Kierkegaard, Feuerbach, Max Brentano, Meinong, Frege, Dilthey, Bergson, Nietzsche, Husserl, Freud, Wittgenstein, Heidegger, hermeneutics, Sartre, Postmodernism, Structuralism, (...) Foucault, and Derrida. (shrink)

This section contains four original articles addressing the matters of interaction, coexistence and representation of the human senses in various historical and cultural contexts. The multisensory experience of the world in relations to the past, the present and the future constitutes the main theme of the selected articles. The authors analyze how, in various cultural texts and historical moments, human experience was depicted through the prism of sensory perception, sometimes combined with sensory memory and the powerfulness/powerlessness of the (non)human corporeality. (...) The authors analyze a variety of historical and cultural sources to answer the question of the impact of multisensory experience on our view of the world: in the past, the present and the future. Nina C. Rastinger in her article “Capturing Extraordinary Multisensory Experiences in Writing: Reports on Natural Disasters in an 18th Century Newspaper Corpus” deals with written representations of natural disasters, which constitute extraordinary multisensory experiences, in historical newspaper texts. Natalia Giza in her study “Multisensuality in the Satirical Prints of the Georgian Era in England” shows how sensory perception enhanced visual humor in the satirical prints of Georgian England, examining how English caricaturists used various sensory elements such as sight, sound, smell, taste, and touch. Jules Sebastian Skutta in his paper “Tactile Vision and Othering: Ethnographic Engagements and Racial Differentiations in 19th Century Travelogues” demonstrates on the basis of ethnographic travelogues from German East Africa and from the time of German colonial rule that the transmission, emergence, and dissemination of features of racial differentiation are based on the interplay of different sensory perceptions. Finally, Bartosz Mroczkowski, in the article entitled “Designing the Future Through Touch” focuses on the sense of touch in the process of designing the future. The aforementioned articles illustrate that multisensuality is a multidimensional concept that requires a thorough analysis from different academic perspectives and with the use of various methodological approaches. (shrink)

This book discusses American pragmatism as it is found in the writings of its three major advocates: Charles S. Peirce, William James, and John Dewey. This book discusses each man's definition of pragmatism and shows how each of them applied it to one basic concept: Peirce to a theory of reality; James to a notion of truth; and Dewey to the concept of God.

The Phenomenology of Spirit was Hegel's grandest experiement, changing our vision of the world and the very nature of philosophical enterprise. In this book, Solomon captures the bold and exhilarating spirit, presenting the Phenomenology as a thoroughly personal as well as philosophical work. He begins with a historical introduction, which lays the groundwork for a section-by-section analysis of the Phenomenology. Both the initiated as well as readers unacquainted with the intricacies of German idealism will find this to be an accessible (...) and exciting introduction to this great philosopher's monumental work. (shrink)

'Original and provocative . . . engagingly written. (C Fred Alford) counters Levinas's notorious obscurity with a goodly dose of transparency' - John Lechte, Macquarrie University Abstract and evocative, writing in what can only be ...

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)